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SDZ-MKS 492

CAT: 0804-HY-100164-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100164-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE) . SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF) -induced bronchoconstriction and allergic reactions in guinea pigs and rats[1].
CAS Number
114606-56-3
Product Name Alternative
MKS 492
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sdz-mks-492.html
Purity
99.77
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(N1C)N(C)C2=C(N(CCOC)C(N[C@H](C3=CC=C(OC)C(OC)=C3)CO)=N2)C1=O
Molecular Formula
C20H27N5O6
Molecular Weight
433.46
References & Citations
[1]Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63 (4) :405-13.|[2]Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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