Products for Research Use Only
RegisterLogin

MSG606 (TFA)

CAT: 0804-HY-P1726ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P1726ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MSG606 TFA is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 TFA can abolish the neuroprotective effects of BMS-470539 (MC1R agonist). MSG606 TFA can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 TFA can delay pain hypersensitivity and reduce cholesterol levels. MSG606 TFA can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH)[2][3][4].
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/msg606-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.O=C([C@@H](NC([C@H](NC([C@@H](NC(CNC(CCCSC[C@H](NC1=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)N[C@@H]1CC5=CNC6=CC=CC=C56
Molecular Formula
C62H82N20O13S.xC2HF3O2
Molecular Weight
1347.51 (free base)
References & Citations
[1]Xu W, et al. Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats. Neurotherapeutics. 2020 Jan;17 (1) :294-308.|[2]Juni A, et al. Sex-specific mediaion of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology. 2010 Jan;112 (1) :181-8.|[3]Chelakkot VS, et al. MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression. NPJ Precis Oncol. 2023 Sep 7;7 (1) :85.|[4]Rinne P, et al. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation. 2017 Jul 4;136 (1) :83-97.
Shipping Conditions
Room Temperature
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC1R

Related Products

CatalogName
HY-P1726-01MSG606
HY-P5380ATNO211 (TFA)
HY-P4668A-01Valylleucine (TFA)
HY-P11296A-01LLVK (TFA)
HY-P10927A-01BRP (TFA)
HY-P10333A-01LIH383 (TFA)
HY-P3970D-01KQFK (TFA)
HY-P3460A-01TDSRCVIGLYHPPLQVY (TFA)
HY-P1723ASpexin (TFA)
HY-P10471A-01MPSD (TFA)

Alternative Products

CatalogName
T76003-01MSG606 TFA
BA5541-10MSG606
A8967-1EZM0414 TFA
C8651-10Pentosidine TFA
A8958-100Box5 TFA
B5867-200SCH772984 TFA
B8792-5GsMTx4 TFA
CS-O-15602Doxorubicinol TFA
PP50168-01Apraglutide TFA
330135Gardiquimod TFA

Popular Products