Products for Research Use Only
RegisterLogin

AQX-435

CAT: 0804-HY-136268-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-136268-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AQX-435 is a potent SHIP1 phosphatase activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth[1][2].
CAS Number
1619983-52-6
UNSPSC
12352005
Target
Apoptosis; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/aqx-435.html
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CN=C1)N[C@@H]2C[C@@]3([H])C(C)(C)CCC[C@]3(C)[C@@H](C(C4=CC(O)=CC(O)=C4)=O)[C@@H]2C
Molecular Formula
C27H34N2O4
Molecular Weight
450.57
References & Citations
[1]Lyoyd F. MACKENZIE, et al. Ship1 modulators and methods related thereto.WO2014110036A1.|[2]Lemm EA, et al. Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells. Clin Cancer Res. 2020;26 (7) :1700-1711.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-115620-01AQX-016A
HY-129982-01SC-435
HY-W953202CRBN ligand-435
HY-112719-01BRD 4354
HY-150507JNJ-4355
HY-112719BBRD 4354 (ditrifluoroacetate)

Alternative Products

CatalogName
GTR19185863-01AQX-435
MBS5825288AQX-016A
M15953-01AQX 1125
MBS5773518AQX-MN115
A22254-25AQX-016A 25mg
A22254-10AQX-016A 10mg
A22254-50AQX-016A 50mg
A22254-100AQX-016A 100mg
A22254-5AQX-016A 5mg
A22254-1AQX-016A 1mg

Popular Products