SMARCA2 degrader-17

SMARCA2 degrader-17

• CAS Number: 2755761-78-3
• UNSPSC Description: SMARCA2 degrader-17 (Compound 1) is a SMARCA2 degrader. SMARCA2 degrader-17 shows synergistic anti-proliferation effects with Adagrasib (HY-130149) in cancer cells. SMARCA2 degrader-17 inhibits tumor growth[1].
• Target Antigen: Epigenetic Reader Domain
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/smarca2-degrader-17.html
• Smiles: OC1=C(C=CC=C1)C2=NN=C3NC[C@](CN([C@H]4CN(CC4)C[C@H](C)OC5=NOC([C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=C5)CC9)([H])N9C3=C2
• Molecular Weight: 891.09
• References & Citations: [1]Koichi Ito, et al. Improved treatment of cancers using combinations of smarca2 degraders and kras targeting therapies. Patent. WO2024076985A2
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported