PSB-06126

• Description :

  PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC50 value of 7.76 μM and a Ki value of 4.39 μM[1][2].

• UNSPSC :

  12352005

• Target :

  NTPDase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/psb-06126.html

• Purity :

  99.83

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=S(C(C(N)=C1C2=O)=CC(NC3=C4C=CC=CC4=CC=C3)=C1C(C5=C2C=CC=C5)=O)(O[Na])=O

• Molecular Formula :

  C24H15N2NaO5S

• Molecular Weight :

  466.44

• References & Citations :

  [1]Younis Baqi, et al. Ecto-nucleotidase inhibitors: recent developments in drug discovery. Mini Rev Med Chem. 2015;15 (1) :21-33.|[2]Amelie Fiene, et al. Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity. Analyst. 2015 Jan 7;140 (1) :140-8.|[3]J B Noronha-Matos, et al. Mesenchymal Stem Cells Ageing: Targeting the "Purinome" to Promote Osteogenic Differentiation and Bone Repair. J Cell Physiol. 2016 Sep;231 (9) :1852-61.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1052089-16-3]