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Ketoconazole (Standard)

CAT: 0804-HY-B0105R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0105R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ketoconazole (Standard) is the analytical standard of Ketoconazole. This product is intended for research and analytical applications. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
CAS Number
65277-42-1
Product Name Alternative
Ketoconazol (Standard) ; R 41400 (Standard)
UNSPSC
12352005
Hazard Statement
H301-H360-H373-H400-H410
Target
Bacterial; Cytochrome P450; Fungal; Ras; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/ketoconazole-standard.html
Smiles
CC(N1CCN(C2=CC=C(OC[C@@H]3O[C@@](CN4C=CN=C4)(C5=CC=C(Cl)C=C5Cl)OC3)C=C2)CC1)=O
Molecular Formula
C26H28Cl2N4O4
Molecular Weight
531.43
Precautions
P260-P264-P270-P273-P280-P330-P391-P405-P501
References & Citations
[1]Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51 (2) :165-75.|[2]Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24 (8) :367-70.|[3]Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151 (9) :4301-12.|[4]Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8 (1) :8161.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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