Ketoconazole-d4

• Description:

  Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

• Product Name Alternative:

  Ketoconazol-d4; R 41400-d4

• UNSPSC:

  12352005

• Target:

  Cytochrome P450; Fungal; Ras

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

• Field of Research:

  Infection; Cancer

• Purity:

  99.63

• Solubility:

  10 mM in DMSO|DMSO : 25mg/mL (ultrasonic)

• Smiles:

  CC(N(CC1([2H])[2H])CC([2H])([2H])N1C(C=C2)=CC=C2OC[C@@H](CO3)O[C@]3(C4=C(C=C(C=C4)Cl)Cl)CN5C=CN=C5)=O

• Molecular Formula:

  C26H24D4Cl2N4O4

• Molecular Weight:

  535.46

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51 (2) :165-75.|[3]Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24 (8) :367-70.|[4]Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151 (9) :4301-12.|[5]Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8 (1) :8161.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1398065-75-2]