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Dronedarone (Hydrochloride)

CAT: 0804-HY-75839-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-75839-01Size:5 mg
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Description
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents.
CAS Number
141625-93-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Potassium Channel
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Dronedarone-Hydrochloride.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CS(=O)(NC1=CC=C(OC(CCCC)=C2C(C3=CC=C(OCCCN(CCCC)CCCC)C=C3)=O)C2=C1)=O.[H]Cl
Molecular Formula
C31H45ClN2O5S
Molecular Weight
593.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Bogdan R, et al. Effect of?dronedarone?on Na+, Ca2+ and HCN channels. Naunyn Schmiedebergs Arch Pharmacol.?2011 Apr;383 (4) :347-56.?|[2]Doggrell SA, et al. Dronedarone: an amiodarone analogue. Expert Opin Investig Drugs. 2004 Apr;13 (4) :415-26.|[3]Manning AS, et al. SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. J Cardiovasc Pharmacol. 1995 Sep;26 (3) :453-61.|[4]Breitenstein A, et al. Dronedarone reduces arterial thrombus formation. Basic Res Cardiol. 2012 Nov;107 (6) :302.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Adv Mater. 2024 Jun;36 (24) :e2311760.|Int J Mol Sci. 2025 May 1;26 (9) :4304.|bioRxiv. 2025 Nov 21:2025.11.20.689520.

Chemical Information

Dronedarone Hydrochloride

Dronedarone Hydrochloride is the hydrochloride salt form of dronedarone, an orally bioavailable benzofuran derivative, with anti-arrhythmic activity. Upon oral administration, and although the exact mechanism of action through which dronedarone exerts its anti-arrhythmic effect has not been fully elucidated, it inhibits multiple voltage-gated ion channels, including sodium, potassium, and calcium ion channels, and restores the normal sinus rhythm and reduces heart rate in atrial fibrillation. It also non-competitively antagonizes adrenergic receptors.

CAS Number141625-93-6
PubChem CID219025
IUPAC NameN-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide;hydrochloride
Molecular FormulaC31H45ClN2O5S
Molecular Weight593.2
Topological Polar Surface Area97.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count18
Heavy Atom Count40
Formal Charge0
Complexity800
SMILES
CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC.Cl
InChI
InChI=1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
InChIKey
DWKVCQXJYURSIQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dronedarone Hydrochloride
CAS: 141625-93-6
CID: 219025
Formula: C31H45ClN2O5S
MW: 593.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight593.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count18
Exact Mass592.2737714
Monoisotopic Mass592.2737714
Topological Polar Surface Area97.2 Ų
Heavy Atom Count40
Formal Charge0
Complexity800
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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