Dronedarone

• UNSPSC Description:

  Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4[1].

• Target Antigen:

  Adrenergic Receptor; Autophagy; Calcium Channel; Cytochrome P450; mAChR; Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Autophagy;GPCR/G Protein;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Dronedarone.html

• Purity:

  99.93

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CCCCC1=C(C2=C(C=CC(NS(C)(=O)=O)=C2)O1)C(C3=CC=C(C=C3)OCCCN(CCCC)CCCC)=O

• Molecular Weight:

  556.76

• References & Citations:

  [1]Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120(7):636-44.|[2]Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna). 2019 Feb;126(2):115-122.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  141626-36-0