GATA2 Recombinant Rabbit Monoclonal Antibody [PSH04-53]

GATA2 Recombinant Rabbit Monoclonal Antibody [PSH04-53]

• Description: GATA2 or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes. It regulates many genes that are critical for the embryonic development, self-renewal, maintenance, and functionality of blood-forming, lympathic system-forming, and other tissue-forming stem cells. GATA2 is encoded by the GATA2 gene, a gene which often suffers germline and somatic mutations which lead to a wide range of familial and sporadic diseases, respectively. The gene and its product are targets for the treatment of these diseases. Inactivating mutations of the GATA2 gene cause a reduction in the cellular levels of GATA2 and the development of a wide range of familial hematological, immunological, lymphatic, and/or other disorders that are grouped together into a common disease termed GATA2 deficiency. Less commonly, these disorders are associated with non-familial (i.e. sporadic or acquired) GATA inactivating mutations. GATA2 deficiency often begins with seemingly benign abnormalities but if untreated progresses to life-threatening opportunistic infections, virus-induced cancers, lung failure, the myelodysplastic syndrome (i.e. MDS), and/or acute myeloid leukemia, principally acute myeloid leukemia (AML), less commonly chronic myelomonocytic leukemia (CMML), and rarely a lymphoid leukemia.
• Product Name Alternative: DCML antibody Endothelial transcription factor GATA 2 antibody Endothelial transcription factor GATA-2 antibody Endothelial transcription factor GATA2 antibody FLJ45948 antibody GATA 2 antibody GATA binding protein 2 antibody GATA-binding protein 2 antibody Gata2 antibody GATA2_HUMAN antibody IMD21 antibody MGC2306 antibody MONOMAC antibody NFE 1B antibody NFE1B antibody OTTHUMP00000216240 antibody
• Abbreviation: GATA2
• CAS Number: 9000-83-3
• Swiss Prot: P23769 Human, Q924Y4 Rat
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Rat
• Immunogen: Synthetic peptide within human GATA2 aa 1-50.
• Isotype: IgG
• Clone: PSH04-53
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell
• Positive Control: SH-SY5Y cell lysate, LNCaP cell lysate, PC-12 cell lysate, SH-SY5Y.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 51 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes