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PD 136450

CAT: 0804-HY-120381Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120381Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PD 136450 (CAM 1189) is an antagonist for cholecystokinin 2 (CCK2) . PD 136450 exhibits anti-secretory, anxiolytic and anti-ulcer activities, inhibits gastric acid secretion (IC50=1 mg/kg), and ameliorates the haemorrhagic lesions (IC50=4.7 mg/kg) in rats[1].
CAS Number
139067-52-0
Product Name Alternative
CAM 1189
UNSPSC
12352005
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pd-136450.html
Smiles
O=C(/C=C/C(N[C@@H](CNC([C@@](C)(CC1=CNC2=C1C=CC=C2)NC(OC3C4CC(CC3C5)CC5C4)=O)=O)C6=CC=CC=C6)=O)O
Molecular Formula
C35H40N4O6
Molecular Weight
612.72
References & Citations
[1]Bastaki SM, et al., PD-136,450: a CCK2 (gastrin) receptor antagonist with antisecretory, anxiolytic and antiulcer activity. Mol Cell Biochem. 2003 Oct;252 (1-2) :83-90.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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