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7,3′,5′-Trihydroxyflavanone

CAT: 0804-HY-N9391-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N9391-02Size:25 mg
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Description
7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, induces the apoptotic cell death of MCF-7 cells by increasing Bax expression level. 7,3′,5′-Trihydroxyflavanone also exhibits antioxidant activity[1][2].
CAS Number
847375-46-6
UNSPSC
12352005
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7-3-5-trihydroxyflavanone.html
Solubility
10 mM in DMSO
Smiles
O=C1C[C@@H](C2=CC(O)=CC(O)=C2)OC3=CC(O)=CC=C13
Molecular Formula
C15H12O5
Molecular Weight
272.25
References & Citations
[1]Abdullah H, et, al. A natural compound from Hydnophytum formicarium induces apoptosis of MCF-7 cells via up-regulation of Bax. Cancer Cell Int. 2010 May 4;10:14.|[2]Tsvetkov DE, et, al. Components of the extracts of the knot wood of Dalbergia Sissoo Linn. and their antioxidant activity. Russian Chemical Bulletin. 2019 Sep; 68:1756-1762.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

7,3',5'-Trihydroxyflavanone

7,3',5'-Trihydroxyflavanone has been reported in Glycyrrhiza inflata with data available.

CAS Number847375-46-6
PubChem CID12084411
IUPAC Name(2S)-2-(3,5-dihydroxyphenyl)-7-hydroxy-2,3-dihydrochromen-4-one
Molecular FormulaC15H12O5
Molecular Weight272.25
XLogP1.8
Topological Polar Surface Area87
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity361
SMILES
C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC(=CC(=C3)O)O
InChI
InChI=1S/C15H12O5/c16-9-1-2-12-13(19)7-14(20-15(12)6-9)8-3-10(17)5-11(18)4-8/h1-6,14,16-18H,7H2/t14-/m0/s1
InChIKey
OVSYWZXDPOVKQU-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of 7,3',5'-Trihydroxyflavanone
CAS: 847375-46-6
CID: 12084411
Formula: C15H12O5
MW: 272.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight272.25
XLogP31.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass272.06847348
Monoisotopic Mass272.06847348
Topological Polar Surface Area87 Ų
Heavy Atom Count20
Formal Charge0
Complexity361
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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