6,7,4'-Trihydroxyflavanone

CAT:

804-HY-N9602

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CAS Number: 189689-31-4
UNSPSC Description: 6,7,4'-Trihydroxyflavanone is a compound with multiple pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic and protective T-cells from METH-induced deactivation. 6,7,4'-Trihydroxyflavanone has shown potential protective effects in neurotoxicity studies and can be used to inhibit patients with neurodegenerative diseases caused by METH. 6,7,4'-Trihydroxyflavanone inhibits METH-induced neurotoxicity by upregulating the Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways. 6,7,4'-Trihydroxyflavanone can also induce Nrf2 nuclear translocation and HO-1 expression, further enhancing its protective effect on neuronal cells[1].
Target Antigen: Akt
Type: Natural Products
Related Pathways: PI3K/Akt/mTOR
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/6-7-4-trihydroxyflavanone.html
Smiles: O=C1C2=CC(O)=C(O)C=C2O[C@H](C3=CC=C(C=C3)O)C1
Molecular Weight: 272.25
References & Citations: [1]6,7,4'-Trihydroxyflavanone Mitigates Methamphetamine-Induced Neurotoxicity in SH-SY5y Cells via Nrf2/heme Oxyganase-1 and PI3K/Akt/mTOR Signaling Pathways
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-N9602	6,7,4'-Trihydroxyflavanone
HY-N9391-02	7,3′,5′-Trihydroxyflavanone
HY-N9391-03	7,3′,5′-Trihydroxyflavanone
HY-N9391-01	7,3′,5′-Trihydroxyflavanone
HY-N13600	3,5,8,3'-Tetramethoxy-6,7,4',5'-bis(methylenedioxy)flavone