PROTAC FLT-3 degrader 4

• CAS Number:

  2956722-48-6

• UNSPSC Description:

  PROTAC FLT-3 degrader 4 is an orally active CRBN-based FLT3-PROTAC degrader that potently induces FLT3-ITD degradation through the ubiquitin-proteasome system. PROTAC FLT-3 degrader 4 shows highly selective to FLT3-ITD mutant acute myeloid leukemia (AML) cells. (Blue: CRBN ligand, Black: linker; Pink: FLT3 inhibitor)[1].

• Target Antigen:

  Apoptosis; FLT3; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-flt-3-degrader-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC2=CC=C(C=C2/C1=C/C3=C(C(NC(CN4CCN(CC4)CC5CCN(CC5)C6=CC=C7C(N(C(C7=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CN3)C)F

• Molecular Weight:

  736.79

• References & Citations:

  [1]Junwei Wang, et al. Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J Med Chem. 2024 May 9;67(9):7197-7223.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported