PROTAC FLT-3 degrader 4

PROTAC FLT-3 degrader 4

• CAS Number: 2956722-48-6
• UNSPSC Description: PROTAC FLT-3 degrader 4 is an orally active CRBN-based FLT3-PROTAC degrader that potently induces FLT3-ITD degradation through the ubiquitin-proteasome system. PROTAC FLT-3 degrader 4 shows highly selective to FLT3-ITD mutant acute myeloid leukemia (AML) cells. (Blue: CRBN ligand, Black: linker; Pink: FLT3 inhibitor)[1].
• Target Antigen: Apoptosis; FLT3; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-flt-3-degrader-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC2=CC=C(C=C2/C1=C/C3=C(C(NC(CN4CCN(CC4)CC5CCN(CC5)C6=CC=C7C(N(C(C7=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CN3)C)F
• Molecular Weight: 736.79
• References & Citations: [1]Junwei Wang, et al. Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J Med Chem. 2024 May 9;67(9):7197-7223.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported