PROTAC FLT-3 degrader 3

PROTAC FLT-3 degrader 3

• UNSPSC Description: PROTAC FLT-3 degrader 3 (compound 35) is a PROTACs degrader of FLT. PROTAC FLT-3 degrader 3 has antiproliferative activity, with IC50 of 7.55 nM in MV4-11 cells[1].
• Target Antigen: FLT3; PROTACs
• Type: Reference compound
• Related Pathways: PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-flt-3-degrader-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(CCC(N1)=O)N(C2=O)C(C3=C2C(N4CCN(C(CC5CCN(C6=CC=C(C(NC7=NNC(C8=CC(N(CC9=C(Cl)C=CC=C9Cl)C=N%10)=C%10C=C8)=C7)=O)C=C6)CC5)=O)CC4)=CC=C3)=O
• Molecular Weight: 927.83
• References & Citations: [1]Zhijie Wang, et al. Discovery of FLT3-targeting PROTACs with potent antiproliferative activity against acute myeloid leukemia cells harboring FLT3 mutations. Eur J Med Chem. 2024 Feb 14:268:116237.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported