PROTAC FLT-3 degrader 3

• UNSPSC Description:

  PROTAC FLT-3 degrader 3 (compound 35) is a PROTACs degrader of FLT. PROTAC FLT-3 degrader 3 has antiproliferative activity, with IC50 of 7.55 nM in MV4-11 cells[1].

• Target Antigen:

  FLT3; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-flt-3-degrader-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C(CCC(N1)=O)N(C2=O)C(C3=C2C(N4CCN(C(CC5CCN(C6=CC=C(C(NC7=NNC(C8=CC(N(CC9=C(Cl)C=CC=C9Cl)C=N%10)=C%10C=C8)=C7)=O)C=C6)CC5)=O)CC4)=CC=C3)=O

• Molecular Weight:

  927.83

• References & Citations:

  [1]Zhijie Wang, et al. Discovery of FLT3-targeting PROTACs with potent antiproliferative activity against acute myeloid leukemia cells harboring FLT3 mutations. Eur J Med Chem. 2024 Feb 14:268:116237.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported