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DEC-RVRK-CMK (TFA)

CAT: 0804-HY-P5062A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P5062A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM) . The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position[1].
Product Name Alternative
Decanoyl-Arg-Val-Arg-Lys-chloromethylketone (TFA)
UNSPSC
12352209
Target
Furin
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dec-rvrk-cmk-tfa.html
Purity
96.66
Solubility
H2O : 5 mg/mL (ultrasonic)
Smiles
NCCCC[C@@H](C(CCl)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCC)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C34H66ClN11O5.xC2HF3O2
Molecular Weight
744.41 (free base)
References & Citations
[1]Wheatley JL, et al. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A. 2007 Apr 17;104 (16) :6626-31.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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