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Ac-DMLD-CMK (TFA)

CAT: 0804-HY-P10939A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10939A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ac-DMLD-CMK TFA is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK TFA can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK TFA blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK TFA reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin and alleviates the deterioration of kidney function. Ac-DMLD-CMK TFA is promising for research of chemotherapy drug-induced nephrotoxicity[1].
UNSPSC
12352209
Target
Caspase; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Purity
98.44
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClCC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
Molecular Formula
C24H36ClF3N4O11S
Molecular Weight
681.08
References & Citations
[1]Shen X, et al. Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis. 2021 Feb 15;12 (2) :186.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Caspase 3

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