Ac-DMLD-CMK (TFA)

• Description:

  Ac-DMLD-CMK TFA is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK TFA can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK TFA blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK TFA reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK TFA is promising for research of chemotherapy drug-induced nephrotoxicity[1].

• UNSPSC:

  12352209

• Target:

  Caspase; Pyroptosis

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Field of Research:

  Cancer; Inflammation/Immunology

• Purity:

  98.44

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  ClCC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F

• Molecular Formula:

  C24H36ClF3N4O11S

• Molecular Weight:

  681.08

• References & Citations:

  [1]Shen X, et al. Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis. 2021 Feb 15;12 (2) :186.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 3