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AAF-CMK (TFA)

CAT: 0804-HY-129407-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129407-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AAF-CMK TFA (Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK) is a subtilisin-type serine peptidase that removes tripeptides from the free NH2 termini of oligopeptides. AAF-CMK TFA is an irreversible inhibitor of TPPII and is typically used at concentrations of 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at a concentration of 50 μM.
CAS Number
184901-82-4
Product Name Alternative
Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK; Tripeptidyl Peptidase inhibitor II
UNSPSC
12352005
Target
Proteasome
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/aaf-cmk-tfa.html
Smiles
C[C@@H](C(N)=O)N(C([C@H](C)N)=O)[C@@H](CC1=CC=CC=C1)C(CCl)=O.O=C(O)C(F)(F)F
Molecular Formula
C18H23ClF3N3O5
Molecular Weight
453.84
References & Citations
[1]Macpherson, et al. Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity. Biochem. J. 248 (1), 259-263 (1987) .
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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