AAF-CMK (TFA)

• Description:

  AAF-CMK TFA (Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK) is a subtilisin-type serine peptidase that removes tripeptides from the free NH2 termini of oligopeptides. AAF-CMK TFA is an irreversible inhibitor of TPPII and is typically used at concentrations of 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at a concentration of 50 μM.

• Product Name Alternative:

  Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK; Tripeptidyl Peptidase inhibitor II

• UNSPSC:

  12352005

• Target:

  Proteasome

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/aaf-cmk-tfa.html

• Smiles:

  C[C@@H](C(N)=O)N(C([C@H](C)N)=O)[C@@H](CC1=CC=CC=C1)C(CCl)=O.O=C(O)C(F)(F)F

• Molecular Formula:

  C18H23ClF3N3O5

• Molecular Weight:

  453.84

• References & Citations:

  [1]Macpherson, et al. Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity. Biochem. J. 248 (1), 259-263 (1987) .

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  184901-82-4