ASK1-IN-6

ASK1-IN-6

• CAS Number: 2407451-82-3
• UNSPSC Description: ASK1-IN-6 (Compound 32) is a selective inhibitor for apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 25 nM. ASK1-IN-6 is blood brain barrier penetrate(rat Cl/Clu is 1.6/56 L/h/kg and Kp,uu is 0.46). ASK1-IN-6 exhibits anti-inflammatory avtivity and ameliorates the Alzheimer’s Disease in Tg4510 mouse model[1].
• Target Antigen: MAP3K
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ask1-in-6.html
• Smiles: FC(F)(F)[C@@H](N1C(C2=CC=CC(NC(C3=C(N=CC(F)=C3)OC)=O)=N2)=NN=C1)C
• Molecular Weight: 410.33
• References & Citations: [1]Jones JH, et al., Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo. J Med Chem. 2021 Oct 28;64(20):15402-15419.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported