CE-2072

CAT: 0804-HY-119337Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-119337Size:1 Each
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AVAILABILITY: InStock
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Description
CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease[1].
CAS Number
[208840-22-6]
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ce-2072.html
Smiles
O=C([C@H]1N(CCC1)C([C@@H](NC(OCC2=CC=CC=C2)=O)C(C)C)=O)N[C@@H](C(C)C)C(C3=NN=C(O3)CC4=CC=CC(C)=C4)=O
Molecular Formula
C33H41N5O6
Molecular Weight
603.71
References & Citations
[1]Shapiro L, et al. Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1. FASEB J. 2001 Jan;15 (1) :115-122.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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