CE-2072

• Description :

  CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease[1].

• UNSPSC :

  12352005

• Target :

  Ser/Thr Protease

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ce-2072.html

• Smiles :

  O=C([C@H]1N(CCC1)C([C@@H](NC(OCC2=CC=CC=C2)=O)C(C)C)=O)N[C@@H](C(C)C)C(C3=NN=C(O3)CC4=CC=CC(C)=C4)=O

• Molecular Formula :

  C33H41N5O6

• Molecular Weight :

  603.71

• References & Citations :

  [1]Shapiro L, et al. Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1. FASEB J. 2001 Jan;15 (1) :115-122.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [208840-22-6]