(S) -CE-123

CAT: 0804-HY-163384-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-163384-01Size:5 mg

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Description

(S) -CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC50 of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S) -CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S) -CE-123 improves cognitive and motivational processes in experimental animals[1][2].

CAS Number

2378384-49-5

UNSPSC

12352005

Target

Dopamine Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-ce-123.html

Solubility

10 mM in DMSO

Smiles

O=[S@@](CC1=CN=CS1)C(C2=CC=CC=C2)C3=CC=CC=C3

Molecular Formula

C17H15NOS2

Molecular Weight

313.44

References & Citations

[1]Renee A Rotolo, et al. The Novel Atypical Dopamine Uptake Inhibitor (S) -CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. Front Pharmacol. 2019 Jun 28:10:682. |[2]Eduardo R. Perez Gonzalez, et al. Process Development and Scale-Up of a Novel Atypical DAT Inhibitor (S) -CE-123. ACS Omega 2024, March 4.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T85363-01	(S) -CE-123
T200498-01	SILA-123
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sc-203027	Dihydrorhodamine 123
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