CE-355621

• Target:

  C-Met/HGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Bioactivity:

  CE-355621 is a humanized anti-c-Met IgG1 monoclonal antibody. It effectively binds to human c-Met in A549 cells (KD= 200 pM, IC50= 466 pM) and also binds effectively to c-Met in cynomolgus monkey kidney cells (KD= 610 pM) . CE-355621 inhibits the c-Met signaling pathway by blocking HGF binding and significantly suppresses tumor growth dependent on the c-Met/HGF pathway. It is applicable for research in cancers such as glioblastoma and gastric cancer.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C