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MMPI-1154

CAT: 0804-HY-117970-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117970-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively[1].
CAS Number
1382722-47-5
Product Name Alternative
TNF Protease Inhibitor 2, (R)-TNF Protease Inhibitor 12, AG1776; KNI-774
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mmpi-1154.html
Purity
99.87
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CN=C(CN(CC2=CC=C(F)C=C2)CC3=CC=C(OCC4=CC=CC=C4)C=C3)N1)O
Molecular Formula
C26H24FN3O3
Molecular Weight
445.49
References & Citations
[1]Péter Bencsik, et al. Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection.Front Pharmacol. 2018 Apr 5;9:296.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-1; MMP-13; MMP-2; MMP-9

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