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HZ-1157

CAT: 0804-HY-109571-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109571-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].
CAS Number
1009734-33-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dengue Virus; Flavivirus; HCV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hz-1157.html
Concentration
10mM
Purity
98.16
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
NC1=NC(N)=C2C(OC(C)(C)C)=CC=CC2=N1
Molecular Formula
C12H16N4O
Molecular Weight
232.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Ye Yu, et al. Discovering Novel anti-HCV Compounds With Inhibitory Activities Toward HCV NS3/4A Protease. Acta Pharmacol Sin. 2014 Aug;35 (8) :1074-81.|[2]Bo Chao, et al. Discovery and Optimization of 2,4-diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors. J Med Chem . 2012 Apr 12;55 (7) :3135-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
MBS3607108-01HZ-1157
A22134-500HZ-1157 500mg
A22134-50HZ-1157 50mg
A22134-100HZ-1157 100mg
A22134-10HZ-1157 10mg
A22134-25HZ-1157 25mg
A22134-5HZ-1157 5mg
A22134-2HZ-1157 2mg
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OR1035416-01HZ-PEG16-HZ

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