cis-4-Hydroxy-L-proline
CAT:
804-HY-40136-02
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

cis-4-Hydroxy-L-proline
- CAS Number: 618-27-9
- UNSPSC Description: cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].
- Target Antigen: Endogenous Metabolite
- Type: Natural Products
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Cancer; Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/cis-4-hydroxy-l-proline.html
- Purity: 98.0
- Solubility: DMSO : 4.76 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C)|H2O : 100 mg/mL (ultrasonic)
- Smiles: O=C(O)[C@H](C1)NC[C@H]1O
- Molecular Weight: 131.13
- References & Citations: [1]Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62.|[2]Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4.|[3]Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7.|[4]Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported