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N-Boc-cis-4-Hydroxy-D-proline

CAT: 0804-HY-W002887-01Size: 25 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W002887-01Size:25 g
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Description
N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the Synthesis of ADCs or PROTACs.
CAS Number
135042-12-5
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-boc-cis-4-hydroxy-d-proline.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)OC(N1[C@H](C[C@H](C1)O)C(O)=O)=O
Molecular Formula
C10H17NO5
Molecular Weight
231.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker

Chemical Information

N-Boc-cis-4-hydroxy-D-proline
CAS Number135042-12-5
PubChem CID688616
IUPAC Name(2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Molecular FormulaC10H17NO5
Molecular Weight231.25
XLogP0.3
Topological Polar Surface Area87.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count16
Formal Charge0
Complexity296
SMILES
CC(C)(C)OC(=O)N1C[C@@H](C[C@@H]1C(=O)O)O
InChI
InChI=1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m1/s1
InChIKey
BENKAPCDIOILGV-RNFRBKRXSA-N
Chemical Structure
2D Structure
2D structure of N-Boc-cis-4-hydroxy-D-proline
CAS: 135042-12-5
CID: 688616
Formula: C10H17NO5
MW: 231.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight231.25
XLogP30.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass231.11067264
Monoisotopic Mass231.11067264
Topological Polar Surface Area87.1 Ų
Heavy Atom Count16
Formal Charge0
Complexity296
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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