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Cis-4-Hydroxy-L-proline (Standard)

CAT: 0804-HY-40136R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-40136R-01Size:10 mg
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Description
Cis-4-Hydroxy-L-proline (Standard) is the analytical standard of cis-4-Hydroxy-L-proline. This product is intended for research and analytical applications. cis-4-Hydroxy-L-proline is an orally active proline analog and collagen production inhibitor. cis-4-Hydroxy-L-proline inhibits cell growth by preventing the deposition of triple helical collagen on the cell layer. cis-4-Hydroxy-L-proline inhibits N-nitrosomethylurea-induced breast tumor growth. cis-4-Hydroxy-L-proline improves lung compliance and reduces prostate weight. cis-4-Hydroxy-L-proline can be used in the study of hypoxic pulmonary hypertension[1][2][3][4][5][6][7][8][9][10].
CAS Number
618-27-9
UNSPSC
12352005
Target
Endogenous Metabolite; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Endocrinology; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cis-4-hydroxy-l-proline-standard.html
Smiles
O=C(O)[C@H](C1)NC[C@H]1O
Molecular Formula
C5H9NO3
Molecular Weight
131.13
References & Citations
[1]Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41 (7) :2855-62.|[2]Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266 (5597) :63-4.|[3]Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80 (4) :261-7.|[4]Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123 (4 Pt 1) :388-93.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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