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N-Boc-cis-4-hydroxy-L-proline

CAT: 0804-HY-W002886-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W002886-01Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
CAS Number
87691-27-8
UNSPSC
12352203
Hazard Statement
H315, H319, H335, H400
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-boc-cis-4-hydroxy-l-proline.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)OC(N1[C@@H](C[C@@H](C1)O)C(O)=O)=O
Molecular Formula
C10H17NO5
Molecular Weight
231.25
Precautions
H315, H319, H335, H400
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker

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