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TLR7 agonist 22

CAT: 0804-HY-162579Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162579Size:1 Each
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Description
TLR7 agonist 22 (Compound 11a) emerges as a selective TLR7 agonist with an IC50 value of 25.86 μM. TLR7 agonist 22 inhibits the cellular HBsAg secretion and effectively activates TLR7, thereby inducing the secretion of TLR7-regulated cytokines IL-12, TNF-αand IFN-αin human PBMC cells. TLR7 agonist 22 is a promising for research in the field of developing novel immunomodulatory anti-HBV agents[1].
CAS Number
3036114-68-5
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-22.html
Smiles
FC1=C(OCC2=NC(CC(N3CCC4=C3C=CC=C4)=O)=CS2)C=CC=C1
Molecular Formula
C20H17FN2O2S
Molecular Weight
368.42
References & Citations
[1]Li S, et al. Exploration of 1- (indolin-1-yl) -2- (thiazol-2-yl) ethan-1-one derivatives as novel anti-HBV agent with potential TLR7 agonist 22onistic effect. Eur J Med Chem. 2024 Jun 8;275:116575.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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