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TLR7 agonist 29

CAT: 0804-HY-173070Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173070Size:1 Each
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Description
TLR7 agonist 29 (Compound 1) is the agonist for TLR7 with an EC50 of 5.2 nM for human TLR7 (EC50 for mouse TLR7 is 48.2 nM) . TLR7 agonist 29 activates bone marrow-derived macrophages (BMDMs), stimulates myeloid cells in the tumor microenvironment, promotes the expression of PD-L1, CD86 and IFN-α. TLR7 agonist 29 can be used as payload for synthesis of ADC[1].
CAS Number
2275612-76-3
UNSPSC
12352005
Target
ADC Payload; IFNAR; PD-1/PD-L1; Toll-like Receptor (TLR)
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
NC1=C2C(N(CC3=CN=C(CNC4CCC4)C=C3)C(O)=N2)=NC(OCCCC)=N1
Molecular Formula
C20H27N7O2
Molecular Weight
397.47
References & Citations
[1]Sega E, et al., Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells. Bioconjug Chem. 2025 Feb 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7

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