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17β-HSD1-IN-2

CAT: 0804-HY-129433-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129433-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (Ki=368 nM) . 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders[1].
CAS Number
1318265-18-7
UNSPSC
12352005
Target
17β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/17β-hsd1-in-2.html
Smiles
O=C(N)C1=CC=CC(C[C@H]2C[C@@]3([H])[C@]4([H])CCC5=C(C=CC(CCBr)=C5)[C@@]4([H])CC[C@]3(C)[C@H]2O)=C1
Molecular Formula
C28H34BrNO2
Molecular Weight
496.48
References & Citations
[1]Trottier A, et al. Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Biochem Pharmacol. 2017 Nov 15;144:149-161.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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