CCZ01048 (TFA)

• UNSPSC Description:

  CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma[1].

• Target Antigen:

  Melanocortin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ccz01048-tfa.html

• Purity:

  98.48

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](CCCCNC4=O)C(N)=O)=O)=O)CCCNC(N)=N)=O)=O)CC5=CN=CN5)[C@H](C4)NC([C@H](CCCC)NC(CN6CCC(NC(CN7CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC7)=O)CC6)=O)=O.OC(C(F)(F)F)=O

• Molecular Weight:

  1622.75

• References & Citations:

  [1]Zhang C, et al. Preclinical Melanoma Imaging with 68Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET. Theranostics. 2017;7(4):805-813. Published 2017 Feb 8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported