CCZ01048

• Description :

  CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma[1].

• UNSPSC :

  12352209

• Target :

  Melanocortin Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ccz01048.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](CCCCNC4=O)C(N)=O)=O)=O)CCCNC(N)=N)=O)=O)CC5=CN=CN5)[C@H](C4)NC([C@H](CCCC)NC(CN6CCC(NC(CN7CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC7)=O)CC6)=O)=O

• Molecular Formula :

  C71H105N21O16

• Molecular Weight :

  1508.72

• References & Citations :

  [1]Zhang C, et al. Preclinical Melanoma Imaging with 68Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET. Theranostics. 2017;7 (4) :805-813. Published 2017 Feb 8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  MC1R