CCZ01048

• Description:

  CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma[1].

• UNSPSC:

  12352209

• Target:

  Melanocortin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ccz01048.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N[C@H] (C (N[C@H] (CC1=CC=CC=C1) C (N[C@H] (C (N[C@@H] (CC2=CNC3=C2C=CC=C3) C (N[C@@H] (CCCCNC4=O) C (N) =O) =O) =O) CCCNC (N) =N) =O) =O) CC5=CN=CN5) [C@H] (C4) NC ([C@H] (CCCC) NC (CN6CCC (NC (CN7CCN (CC (O) =O) CCN (CC (O) =O) CCN (CC (O) =O) CC7) =O) CC6) =O) =O

• Molecular Formula:

  C71H105N21O16

• Molecular Weight:

  1508.72

• References & Citations:

  [1]Zhang C, et al. Preclinical Melanoma Imaging with 68Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET. Theranostics. 2017;7 (4) :805-813. Published 2017 Feb 8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  MC1R