EGFR-IN-127

• UNSPSC Description:

  EGFR-IN-127 is an ATP-competitive EGFR inhibitor with IC50s of 136.3 nM and 161. 2 nM for EGFRdel19 and EGFRdel19/T790M/C797S, respectively. EGFR-IN-127 has the potential for the study of non-small-cell lung cancer (NSCLC)[1].

• Target Antigen:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/egfr-in-127.html

• Smiles:

  O=C(O)CN(CCN(CC(O)=O)C1)CC(NC2=CC3=C(N=CN=C3NC4=CC(F)=CC=C4)C=C2NC1=O)=O

• Molecular Weight:

  525.49

• References & Citations:

  [1]Liang-Liang Guo, et al. Design and activity evaluation of new EGFR tyrosine kinase inhibitors containing cyclic polyamines. Bioorg Med Chem Lett. 2024 Sep 14:113:129961.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported