KFU-127

• Description :

  KFU-127 (Compound 6b) is a broad spectrum topical antimicrobial capable of one-shot targeting of bacterial and fungal-bacterial biofilms. KFU-127 is considerably toxic for eukaryotic cells[1]. KFU-127 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Target :

  Bacterial; Fungal

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/kfu-127.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCC1OCC2=C(C(C[N+](C/C=C/C#CC(C)(C)C)(CC3=C4C=CC=CC4=CC=C3)C)=NC(C)=C2O1)CO.[Br-]

• Molecular Formula :

  C34H43BrN2O3

• Molecular Weight :

  607.62

• References & Citations :

  [1]Garipov MR, et al. Targeting pathogenic fungi, bacteria and fungal-bacterial biofilms by newly synthesized quaternary ammonium derivative of pyridoxine and terbinafine with dual action profile. Bioorg Chem. 2020 Nov;104:104306.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported