Anticancer agent 127

• Description:

  Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects[1].

• UNSPSC:

  12352005

• Target:

  IAP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-127.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1[C@H](C(N[C@H]2C(C=CC=C3OS(=O)(F)=O)=C3CC2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O

• Molecular Formula:

  C26H37FN4O6S

• Molecular Weight:

  552.66

• References & Citations:

  [1]Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66 (12) :8159-8169.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2410953-19-2]