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ATF6 antibody

CAT: 0710-FNab10404Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10404Size:100 µg
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Background
Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed 50kd cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N (9) -CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') . Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Synonyms
Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) |Activating transcription factor 6 alpha (ATF6-alpha) |Processed cyclic AMP-dependent transcription factor ATF-6 alpha|ATF6
Gene ID
22926
UniProt
P18850
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Activating transcription factor 6
Target
ATF6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa, 100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
1-182aa

UniProtKB · P18850

Cyclic AMP-dependent transcription factor ATF-6 alpha

ATF6A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P18850
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATF6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
cAMP-dependent transcription factor ATF-6 alpha
EC number
—
Processing
—
Secondary accessions
O15139, Q5VW62, Q6IPB5, Q9UEC9
Protein keywords

Molecular function

ActivatorDNA-binding

Disease

Disease variant

Cellular component

Endoplasmic reticulumGolgi apparatusMembraneNucleus

PTM

GlycoproteinIsopeptide bondUbl conjugation

Technical term

Proteomics identificationReference proteome

Domain

Signal-anchorTransmembraneTransmembrane helix

Biological process

TranscriptionTranscription regulationUnfolded protein response

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