ATF2 antibody

• Background :

  This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene

• Synonyms :

  Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) |Activating transcription factor 2|Cyclic AMP-responsive element-binding protein 2 (CREB-2, cAMP-responsive element-binding protein 2) |HB16|cAMP response element-binding protein CRE-BP1|ATF2|CREB2|CREBP1

• Gene ID :

  1386

• UniProt :

  P15336

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Activating transcription factor 2

• Target :

  ATF2

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IF

• Field of Research :

  Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  70 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IF