ATF4 antibody

CAT: 0710-FNab00662Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab00662Size:100 µg
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Background
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity) . It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088) .
Synonyms
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) |Activating transcription factor 4|Cyclic AMP-responsive element-binding protein 2 (CREB-2, cAMP-responsive element-binding protein 2) |Tax-responsive enhancer element-binding protein 67 (TaxREB67) |ATF4|CREB2|TXREB
Gene ID
468
UniProt
P18848
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Activating transcription factor 4 (tax-responsive enhancer element B67)
Target
ATF4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP, FC
Field of Research
Neuroscience, Epigenetics, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-58 kDa, 35-38 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP, FC

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