CDK2/MDM2-IN-1

CAT: 0804-HY-163357Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-163357Size:1 Each

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Description

CDK2/MDM2-IN-1 (III-13) is a dual inhibitor of CDK2/MDM2 with an IC50 value of 2.60 nM for CDK2. CDK2/MDM2-IN-1 has antitumor activity[1].

CAS Number

3083904-06-4

UNSPSC

12352005

Target

CDK; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk2-mdm2-in-1.html

Solubility

10 mM in DMSO

Smiles

[H][C@]1(C2=CC(NC(CC3=CC=C(N4CCCC4=O)C=C3)=O)=NN2)CC[C@@H](OC(N5CCC5(C)C)=O)C1

Molecular Formula

C26H33N5O4

Molecular Weight

479.57

References & Citations

[1]Liu Z, et al. Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53. Molecules. 2024 Feb 4;29 (3) :725.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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