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4-Hydroxyestrone-13C6

CAT: 0804-HY-W009300S1-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W009300S1-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroxyestrone-13C6 is a 13C-labeled 4-Hydroxyestrone. 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].
Product Name Alternative
4-OHE1-13C6
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/4-hydroxyestrone-13c6.html
Solubility
10 mM in DMSO
Smiles
[13CH3][13C@]12[13C@]([H])([C@]3([C@@]([H])(C4=CC=C(C(O)=C4CC3)O)CC2)[H])[13CH2][13CH2][13C]1=O
Molecular Formula
C12 13C6H22O3
Molecular Weight
292.32
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-234.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-234.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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