2-Hydroxyestrone

• Description :

  2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

• Product Name Alternative :

  Catecholestrone

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/2-hydroxyestrone.html

• Purity :

  98.57

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=C(C=C(O)C(O)=C4)[C@@]3([H])CC1)C2=O

• Molecular Formula :

  C18H22O3

• Molecular Weight :

  286.37

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]H L Bradlow, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.|[2]J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259 (8) :4840-5.|[3]M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13 (12) :1208-13.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Estrogen receptor; Human Endogenous Metabolite

• CAS Number :

  [362-06-1]