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4-Hydroxyestrone

CAT: 0804-HY-W009300-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W009300-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].
CAS Number
3131-23-5
Product Name Alternative
4-OHE1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxyestrone.html
Purity
99.0
Solubility
10 mM in DMSO|Methanol : ≥ 10mg/mL
Smiles
OC(C=C1)=C(O)C(CC[C@@]2([H])[C@]3([H])CC4)=C1[C@@]2([H])CC[C@]3(C)C4=O
Molecular Formula
C18H22O3
Molecular Weight
286.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Hye Joung Choi, et al. 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. Sci Rep. 2020 Apr 29;10 (1) :7283.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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