2-Hydroxyestrone-13C6

• Description:

  2-Hydroxyestrone-13C6 is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

• Product Name Alternative:

  Catecholestrone-13C6

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/2-hydroxyestrone-13c6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [13CH3][13C@@]12[13C@]([13CH2][13CH2][13C]2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(O)=C(O)C=C4CC3

• Molecular Formula:

  C12 13C6H22O3

• Molecular Weight:

  292.32

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]H L Bradlow, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.|[3]J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259 (8) :4840-5.|[4]M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13 (12) :1208-13.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported