2-Hydroxyestrone-d4

• UNSPSC Description:

  2-Hydroxyestrone-d4 is the deuterium labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

• Target Antigen:

  Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer; Endocrinology

• Purity:

  95.43

• Solubility:

  DMSO : 30 mg/mL (ultrasonic;warming)

• Smiles:

  C[C@@]12[C@](CC([2H])([2H])C2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=C([2H])C(O)=C(O)C([2H])=C4CC3

• Molecular Weight:

  290.39

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]H L Bradlow, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.|[3]J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.|[4]M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  81586-97-2