Endoxifen (hydrochloride)

• UNSPSC Description:

  Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study[1][2].

• Target Antigen:

  Cytochrome P450; Drug Metabolite; Estrogen Receptor/ERR; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Endoxifen-hydrochloride.html

• Purity:

  98.75

• Solubility:

  DMSO : ≥ 35 mg/mL|H2O : < 0.1 mg/mL

• Smiles:

  OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1.[H]Cl

• Molecular Weight:

  409.95

• References & Citations:

  [1]Wu X, et al. The tamoxifen metabolite, Endoxifen, is a potent antiestrogen that targets estrogen receptor alpha fordegradation in breast cancer cells. Cancer Res. 2009 Mar 1;69(5):1722-7.|[2]Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec;23(14):1233-4, 1236.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Phase 3

• CAS Number:

  1197194-41-4