Endoxifen (Z-isomer)

• UNSPSC Description:

  Endoxifen Z-isomer is the most important Tamoxifen metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC50 value of 1.6 μM.

• Target Antigen:

  Estrogen Receptor/ERR; Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Endoxifen-Z-isomer.html

• Purity:

  99.20

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1

• Molecular Weight:

  373.49

• References & Citations:

  [1]Chae YJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7.|[2]Wu X, et al. Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011 Mar 10;13(2):R27.North Dakota State University of Agriculture and Applied Science. 2018 Feb.|J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Mar 26:1237:124100.|Sci Rep. 2022 Jan 31;12(1):1643.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 3

• CAS Number:

  112093-28-4