Products for Research Use Only
RegisterLogin

Tepotinib (hydrochloride)

CAT: 0804-HY-14721ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14721ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tepotinib (EMD-1214063) hydrochloride is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC50 of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib hydrochloride inhibits c-Met phosphorylation and induces autophagy. Tepotinib hydrochloride has antitumor effects[1][2][3].
CAS Number
1103508-80-0
Product Name Alternative
EMD-1214063 (hydrochloride)
UNSPSC
12352005
Target
Autophagy; c-Met/HGFR
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tepotinib-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=CC(C(C=CC2=O)=NN2CC3=CC=CC(C4=NC=C(C=N4)OCC5CCN(CC5)C)=C3)=C1.[H]Cl.[x]
Molecular Formula
C29H28N6O2.xHCl
Molecular Weight
492.57 (free base)
References & Citations
[1]Bladt F, et al. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res, 2013, 19 (11), 2941-2951.|[2]A. Naing, et al. IS4-1 - A Phase I Dose-Escalation Study of emd 1214063, an Oral Selective CMET Inhibitor, in Patients with Advanced Solid Tumors. Annals of Oncology. Volume 23, Supplement 11, October 2012, Page xi21.|[3]Zhan N, et al. The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model. Gene Expr. 2018 May 18;18 (2) :135-147.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

tepotinib hydrochloride anhydrous
CAS Number1103508-80-0
PubChem CID25171647
IUPAC Name3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile;hydrochloride
Molecular FormulaC29H29ClN6O2
Molecular Weight529.0
Topological Polar Surface Area94.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count38
Formal Charge0
Complexity880
SMILES
CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N.Cl
InChI
InChI=1S/C29H28N6O2.ClH/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30;/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3;1H
InChIKey
YHHHGHDGBUUWIS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of tepotinib hydrochloride anhydrous
CAS: 1103508-80-0
CID: 25171647
Formula: C29H29ClN6O2
MW: 529.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight529.0
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass528.2040519
Monoisotopic Mass528.2040519
Topological Polar Surface Area94.7 Ų
Heavy Atom Count38
Formal Charge0
Complexity880
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-14721-01Tepotinib
HY-14721R-01Tepotinib (Standard)
HY-B0500BAlverine (hydrochloride)
HY-W714513VU0469650 (hydrochloride)
HY-W708286-01α-Pyrrolidinobutiothiophenone (hydrochloride)
HY-W492795Quifenadine (hydrochloride)
HY-W012179-01Phenylpiperazine (hydrochloride)
HY-Z6449-01Phenylephrone (hydrochloride)
HY-W209279(±) Anabasine (hydrochloride)
HY-W027446-01Pyridoxal hydrochloride

Alternative Products

CatalogName
T9601-01Tepotinib hydrochloride (1 : x)
MBS5786449Tepotinib hydrochloride(1:x)
abx283530-01Tepotinib
RM-T283007-01Tepotinib Impurity 7
RM-T283006-01Tepotinib Impurity 6
RM-T283003-01Tepotinib Impurity 3
RM-T283002-01Tepotinib Impurity 2
RM-T283005-01Tepotinib Impurity 5
RM-T283004-01Tepotinib Impurity 4
A11257-100Tepotinib (EMD-1214063) 100mg

Popular Products