Endoxifen

• Description :

  Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332, H361, H413

• Target :

  Cytochrome P450; Drug Metabolite; Estrogen Receptor/ERR; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Endoxifen.html

• Concentration :

  10mM

• Purity :

  99.42

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCNC)C=C3

• Molecular Formula :

  C25H27NO2

• Molecular Weight :

  373.49

• Precautions :

  H302, H312, H332, H361, H413

• References & Citations :

  [1]Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park) . 2009 Dec;23 (14) :1233-4, 1236.|[2]Wu X, et al. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009 Mar 1;69 (5) :1722-7.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  Aromatase/CYP19A1; ERα

• CAS Number :

  [110025-28-0]