Endoxifen

CAT: 0804-HY-18719E-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18719E-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2].
CAS Number
[110025-28-0]
UNSPSC
12352005
Hazard Statement
H302, H312, H332, H361, H413
Target
Cytochrome P450; Drug Metabolite; Estrogen Receptor/ERR; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Endoxifen.html
Concentration
10mM
Purity
99.42
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCNC)C=C3
Molecular Formula
C25H27NO2
Molecular Weight
373.49
Precautions
H302, H312, H332, H361, H413
References & Citations
[1]Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park) . 2009 Dec;23 (14) :1233-4, 1236.|[2]Wu X, et al. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009 Mar 1;69 (5) :1722-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Aromatase/CYP19A1; ERα

Alternative Products

CatalogName
MBS131772Endoxifen
MBS3600698-01Endoxifen hydrochloride
M17762-01Endoxifen HCl
MBS5814116Endoxifen mesylate
MBS3614846-01Endoxifen (E-isomer)

Popular Products