Endoxifen (E-isomer)

• Description:

  Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer exhibits antiestrogenic effects[1][2].

• Product Name Alternative:

  E-Endoxifen

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Endoxifen-E-isomer.html

• Concentration:

  10mM

• Purity:

  98.02

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1

• Molecular Formula:

  C25H27NO2

• Molecular Weight:

  373.49

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Elkins P, et al. Characterization of the isomeric configuration and impurities of (Z) -Endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.|[2]Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35 (10) :1942-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [114828-90-9]