Endoxifen (E-isomer)

CAT: 0804-HY-18719D-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18719D-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer exhibits antiestrogenic effects[1][2].
CAS Number
[114828-90-9]
Product Name Alternative
E-Endoxifen
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Endoxifen-E-isomer.html
Concentration
10mM
Purity
98.02
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1
Molecular Formula
C25H27NO2
Molecular Weight
373.49
Precautions
H315, H319, H335
References & Citations
[1]Elkins P, et al. Characterization of the isomeric configuration and impurities of (Z) -Endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.|[2]Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35 (10) :1942-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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